Blar i forfatter "Öling, Sofia Maria"

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    • Deciphering human cell type enriched transcriptomes across tissue types and the functional study of the endothelial enriched protein KANK3 

      Öling, Sofia Maria (Doctoral thesis; Doktorgradsavhandling, 2023-11-13)
      The identification of cell type-specific genes and their modification under certain conditions is essential for our understanding of the human body. Such knowledge also allows us to study the function of uncharacterised genes in the correct cell type. Single-cell RNA sequencing (scRNAseq) can be used to profile different cell types, but cell removal and processing can introduce artifacts. In the ...

    • A human adipose tissue cell-type transcriptome atlas 

      Norreen-Thorsen, Marthe; Struck, Eike Christopher; Öling, Sofia Maria; Zwahlen, Martin; Von Feilitzen, Kalle; Odeberg, Jacob; Lindskog, Cecilia; Pontén, Fredrik; Uhlén, Mathias; Dusart, Philip James; Butler, Lynn (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-12)
      The importance of defining cell-type-specific genes is well acknowledged. Technological advances facilitate high-resolution sequencing of single cells, but practical challenges remain. Adipose tissue is composed primarily of adipocytes, large buoyant cells requiring extensive, artefact-generating processing for separation and analysis. Thus, adipocyte data are frequently absent from single-cell ...